The main objective of the Action is to build on existing knowledge on chemical and biochemical processes in high-energy localised reaction microenvironments, in order to systematically tune the desired properties of such systems for selective applications in industrial, environmental, synthetic and analytical systems. Sonochemistry and microwave-enhanced chemistry will be employed, singly and in combination with each other or with lectrochemistry and/or photochemistry. It is envisaged that multi-disciplinary teams will be formed to develop the specific activities, with the goal to investigate and further develop applications for these methodologies, which all possess various degrees of novelty within chemistry.